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All pregnant women should be offered the quad screen, but it is recommended for women who: The quad screen measures high and low levels of AFP, abnormal levels of h CG and estriol, and high levels of Inhibin-A.

The results are combined with the mother’s age and ethnicity in order to assess probabilities of potential genetic disorders.

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Low levels of AFP and abnormal levels of h CG and estriol may indicate that the developing baby has Trisomy 21(Down syndrome), Trisomy 18 (Edwards Syndrome) or another type of chromosome abnormality.

It is important to remember that the quad screen is a screening test and not a diagnostic test.

is a protein produced by the placenta and ovaries The quad screen is a maternal blood screening test which is similar to the Triple Screen Test (also know as AFP Plus and the Multiple Marker Screening).

However, the quad screen looks for not only the three specific substances evaluated in those tests (AFP, h CG, and Estriol) but also a fourth substance known as Inhibin-A.

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These tests DO NOT diagnose a problem; they only signal that further testing should be done.

The quad screen test involves drawing blood from the mother, which takes about 5 to 10 minutes.

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